Challenges in the Simulation of Drying in Fluid Bed Granulation

Fluid bed granulation is faced with a high level of complexity due to the simultaneous occurrence agglomeration, breakage, and drying. These complexities should be thoroughly investigated through particle–particle, particle–droplet, particle–fluid interactions understand process better. The present contribution focuses on importance drying associated challenges when modeling process. To do so, initially, we will summary numerical approaches, from micro-scale macro-scale, used for simulation agglomeration in fluid granulators. Depending modeled scale, each approach features several advantages challenges. We classified imposed based their contributions rate. Then, critically scrutinized how these have been addressed literature. Our review identifies some main related (i) interaction droplets particles; (ii) kinetics granules its dependence agglomeration/breakage processes; as well (iii) determination rates. Concerning latter, specifically surface area available needs differentiated state liquid granule: propose this form liquid, pore bridging primary particles.